Samuel Little (1940–2020) was an American serial killer believed to be the most prolific confirmed serial murderer in United States history. After decades of drifting across the country, Little confessed to murdering 93 women between 1970 and 2005, many of whom were vulnerable individuals whose deaths initially went unsolved. His confessions, detailed victim sketches, and extensive criminal history made his case one of the largest serial murder investigations ever conducted by the FBI.